Micro-spherocyte
Severe membrane defects (e.g. hereditary pyropoikilocytosis). Toxin induced membrane damage: particularly Clostridium perfringens. Infrequent microspherocytes may appear as part of a spectrum of cells in many conditions with erythrocyte damage (e.g. fragmentation) or fragile production (e.g. megaloblastic states).
https://haematologyetc.co.uk/index.php?title=Microspherocytes
Inherited defects
- Severe membrane defects (e.g. hereditary pyropoikilocytosis)
Acquired causes with frequent microspherocytes
- Direct physical damage to the erythrocyte membrane: burns or heated sample
- Toxin induced membrane damage: particularly Clostridium perfringens
Acquired causes with infrequent microspherocytes
- Infrequent microspherocytes may appear as part of a spectrum of cells in many conditions with erythrocyte damage (e.g. fragmentation) or fragile production (e.g. megaloblastic states)
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